Endocrine Abstracts

The use of immune checkpoint inhibitors (ICPI) for treatment of different advanced cancers has opened a new therapeutic window. Thyroid dysfunction is an often side effect described for these drugs.Objectives: To describe the thyroid alterations found in oncologic patients undergoing treatment with ICPI.Materials and methods: A descriptive, retrospective study of oncologic patients receiving treatment with ICPI referred to the Endo...

Introduction: Obesity is a chronic condition with great morbidity, mortality and significant economic and psychosocial impact. Bariatric surgery has proven to be an effective therapy for sustained weight loss and has allowed a reduction in medical comorbidity and an improvement in self-esteem and life quality. However, recent evidence reports an increase in eating and substance-related disorders that are diagnosed in the postoperative period worsening the prognosis.<p clas...

Introduction: The available questionnaires for the detection of hypoglycemia are designed for patients with type 1 Diabetes (T1DM), and do not take into account some characteristics of patients with type 2 Diabetes (T2DM). For instance most of T2DM patients do not perform capillary blood glucose self-monitoring as part of their daily treatment and hypoglycemia might be underestimated. Nevertheless, hypoglycemia can have a negative impact on T2DM patients, in terms of increasin...

Background: The cortisol suppression test with 1 mg dexamethasone (DST) is a screening test for hypercortisolism with high sensitivity (95%) for serum cortisol cut-off <1.8 μg/dl. However, cortisol tests may give false positive in patients with severe obesity (SO). On the other hand, bariatric surgery (BS) is the most effective treatment for SO, and the operated population is growing. At present there is no reliable data regarding the impact of BS on DST results in pa...

Introduction: Morbid obesity (MO) is a major global public health problem, associated with a significant economic burden, both due to its high prevalence and the number and severity of its comorbidities. MO is associated with a high degree of difficulty to lead a normal social and working life. Weight loss is effective in decreasing these risks and to reduce disease severity. Bariatric surgery (BS) is an effective therapy for sustained weight loss and for the improvement of th...

Introduction: Maternal obesity (MO) increases the risk of gestational and neonatal complications. Bariatric surgery (BS) is currently the most effective long-term treatment of MO. The sustained weight loss after BS reduces the risk of maternal comorbidities during pregnancy. Nevertheless, BS is associated with an important risk of nutrients deficiency, and some data indicate that might increase the risk of prematurity and low birth weight. The objective of the present study is...

Introduction: Obesity and its comorbidities, specially type 2 diabetes (T2D), are a major public health problem. The disappointing result of dietary treatment and the scarce of drugs have led to increased bariatric surgery (BS) as the most efficient therapeutic option. However, not all obese patients with T2D who undergo BS achieve diabetes remission.Objective: To develop a genetic scoring system for predicting T2D remission following BS. 2) To compare o...